While Tichu is my personal favorite card game, Mu does for 5 players what Tichu does for 4. What that is to say is that Mu is the best 5 player card game that I've ever played. I don't think that I would ever choose to play another card game over this one if there were five total players.
It's a weird number of players, but if you have the appropriate group, pick this up!
Mü & Lots More is a collection of very interesting trick taking card games. My personal favourite is "Was Sticht?" in which you try to complete specific tasks (e.g. take no tricks) that you draft before starting. A big part of the game is in the task and card drafting, and it gives you a great chance to influence your goals and hand - which also eliminates most of the luck from the game.