Recently received an advance copy of this game by GMT - rest assured the new 3rd edition is just as beautiful and lovingly crafted as their recent 2nd edition run. Definitely pick this one up, even if its the only game of its genre you own.
It's become a popular enough title that people who would normally run in fear from it are still quite interested. I fit this description myself, and I consider Twilight Struggle to be a great afternoon game for two guys (or girls, maybe, nobody I know!) - it's actually fairly light in terms of depth and reliance on skill. There is a moderate luck element to the card aspects of the game. It's very fun, very entertaining, and VERY well made.